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Indometacin
Clinical data
Pronunciation/ ɪ n d oʊ ˈ m ɛ t ə s ɪ n /
Trade namesIndocid, Indocin
AHFS/Drugs.comMonograph
License dataUS   FDA: Indomethacin
Pregnancy categoryAU: C C/D (US)
Routes of administrationOral, rectal, IV, topical
ATC codeC01EB03 ( WHO ) M01AB01 ( WHO ), M02AA23 ( WHO ), S01BC01 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability~100% (oral), 80–90% (rectal)
Protein binding99% [1]
MetabolismHepatic
Elimination half-life2.6-11.2 hours (adults), 12-28 hours (infants) [1]
ExcretionRenal (60%), fecal (33%)

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Comparable studies in rodents using indomethacin sodium doses of aspirin have shown similar indomethacin sodium and fetal effects.Indomethacin and its metabolites are known to be substantially excreted by the kidneys, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, use caution in this patient population, and it may be useful to monitor renal functionsee Clinical Pharmacology 12.

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In this same cohort, the incidence of death in the indomethacin sodium year post-MI was 20 per 100 indomethacin sodium years in NSAID-treated patients compared to 12 per 100 person years in non-NSAID exposed patients. Although the absolute rate of death declined somewhat after the first year post-MI, the increased indomethacin sodium risk of death in NSAID users persisted indomethacin sodium at least the next four years of follow-up.INDOCIN may enable the reduction of steroid dosage in patients receiving steroids for the more severe forms of rheumatoid arthritis.

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Indomethacin and triamterene should not be administered together.nformation structure of indomethacin revised April 2020. Copyrigh c 2020 First Databank, Inc. This survey is being conducted by the WebMD marketing sciences department.

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Goldenberg RL, Iams JD, Mercer BM, et al. The preterm prediction study: the value of new vs standard risk factors in predicting early and all spontaneous preterm births.Maintenance dose: Adjust dose as indomethacin chemical structure and tolerated in increments of 25 mg or 50 mg indomethacin chemical structure until satisfactory response or maximum dose is achieved Comment: For patients who have persistent night pain or morning stiffness, a larger portion of the indomethacin chemical structure daily dose up to 100 mg orally or rectally at bedtime may be helpful and does unisom interact with any medications.

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