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Clinical data
Trade namesPrograf, Advagraf, Protopic, others
License dataEU  EMA:  by INN
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationTopical, oral, iv
ATC codeD11AH01 ( WHO ) L04AD02 ( WHO )
Legal status
Legal statusIn general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability24% (5–67%), less after eating food rich in fat
Protein binding≥98.8%
MetabolismHepatic CYP3A4, CYP3A5
Elimination half-life11.3 h for transplant patients (range 3.5–40.6 h)
ExcretionMostly faecal

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  2. Active substance: tacrolimus
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Akt rk S, Erdo mu, Kumru G, et al. Blunt tacrolimus prograf lab test level in the first time after surgery may decrease acute rejection.

... (Neoral, Sandimmune) · Tacrolimus (FK506, Prograf ) · Cyclophosphamide ( Cytoxan) · Mycophenolate Mofetil (Cellcept) · Sirolimus (Rapamycin, Rapamune)  ...

Glomerular Disease Primer | Kidney Disease Section | NIDDK

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